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DeCS
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Descriptor English:
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Immunoreceptor Tyrosine-Based Activation Motif
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Descriptor Spanish:
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Motivo de Activación del Inmunorreceptor Basado en Tirosina
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Descriptor Portuguese:
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Motivo de Ativação do Imunorreceptor Baseado em Tirosina
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Synonyms English:
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Immune Receptor Tyrosine-Based Activation Motif
Immuno-Receptor Tyrosine-Based Activation Motif
Immune Receptor Tyrosine Based Activation Motif
Immuno Receptor Tyrosine Based Activation Motif
Immunoreceptor Tyrosine Based Activation Motif
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Tree Number:
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G02.111.570.820.709.275.500.440
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Definition English:
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A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses. |
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History Note English:
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2013
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Allowable Qualifiers English:
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Record Number:
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55098
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Unique Identifier:
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D061625
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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